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Product info sheet
| Chemical structure |
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| Chemical name | 2-Amino-4-methyl-7-(naphthalen-1-yl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile |
| CAS no | -- |
| MW | 330.2 |
| Purity | >98% (HPLC) |
| Solubility | Up to 25 mM in DMSO |
| Pharmacology | Ki: 0.42 µM at EAAT1; >300 µM at EAAT2; >300 µM at EAAT3 |
| Bioavailability | Half-life of 30 min in serum after oral administration in rat. Penetrates the blood-brain-barrier (BBB) |
| Litterature references |
(1) Jensen, AA; Erichsen, MN; Nielsen, CW; Stensbøl, TB; Kehler, J and Bunch, L ”Discovery of the First Selective Inhibitor of Human Excitatory Amino Acid Transporter Subtype 1” J. Med. Chem. 2009, 52, 912 (2) Erichsen, MN; Huynh, THV; Abrahamsen, B; Bastlund, JF; Bundgaard, C; Monrad, O; Bekker-Jensen, A; Nielsen, CW; Frydenvang, K; Jensen, AA and Bunch, L “Structure-Activity-Relationship Study of First Selective Inhibitor of Excitatory Amino Acid Transporter Subtype 1: 2-Amino-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile (UCPH-101)”, J. Med. Chem. 2010, 53, 7180-7191 (3) Bunch, L; Erichsen, MN and Jensen, AA “Excitatory Amino Acid Transporters as Potential Drug Targets“ Exp. Opin. Ther. Targ. 2009, 13, 719-731 (4) Huynh, THV; Shim, I; Bohr, H;Abrahamsen B; Nielsen, B; Jensen, AA and Bunch, L “Structure-Activity-Relationship Study of Selective EAAT1 Inhibitor UCPH-101 and Absolute Configurational Assignment using Infrared (IR) and Vibrational Circular Dichroism (VCD) Spectroscopy in Combination with Ab Initio Hartree-Fock Calculations” J. Med. Chem. 2012, 55, 5403-5412 |
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Patents (IPRs) |
WO/2010/066253: SELECTIVE INHIBITORS OF EXCITATORY AMINO ACID TRANSPORTER SUBTYPE 1 (EAAT1/GLAST) by L. Bunch and A. A. Jensen US Patent 20120035361: SELECTIVE INHIBITORS OF EXCITATORY AMINO ACID TRANSPORTER SUBTYPE 1 (EAAT1/GLAST) by L. Bunch and A. A. Jensen |
| Price and Availability |
10 mg: EUR 195,- 50 mg: EUR 795,- 100 mg: Contact us 500 mg: Contact us 1000 mg: Contact us 2000 mg: Contact us
- Prices include free shipping to any destination. Delivery within 1-2 weeks.
The commercial rights to UCPH-102 are covered by patents listed above.All IPRs belong to Hugin NeuroChemicalsResellers must sign aSupply and Onward Sales Agreement
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