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Product info sheet
| Chemical structure |
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| Chemical name | 2-Amino-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile |
| CAS no | 1118460-77-7 |
| MW | 422.48 |
| Purity | >98% |
| Solubility | Up to 25 mM in DMSO |
| Pharmacology | Ki: 0.66 µM at EAAT1; >300 µM at EAAT2; >300 µM at EAAT3 |
| Bioavailability | Half-life of 30 min in serum after oral administration in rat. No penetration of the blood-brain-barrier (BBB) |
| Litterature References |
(1) Jensen, AA; Erichsen, MN; Nielsen, CW; Stensbøl, TB; Kehler, J and Bunch, L ”Discovery of the First Selective Inhibitor of Human Excitatory Amino Acid Transporter Subtype 1” J. Med. Chem. 2009, 52, 912 (2) Erichsen, MN; Huynh, THV; Abrahamsen, B; Bastlund, JF; Bundgaard, C; Monrad, O; Bekker-Jensen, A; Nielsen, CW; Frydenvang, K; Jensen, AA and Bunch, L “Structure-Activity-Relationship Study of First Selective Inhibitor of Excitatory Amino Acid Transporter Subtype 1: 2-Amino-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile (UCPH-101)”, J. Med. Chem. 2010, 53, 7180-7191 (3) Bunch, L; Erichsen, MN and Jensen, AA “Excitatory Amino Acid Transporters as Potential Drug Targets“ Exp. Opin. Ther. Targ. 2009, 13, 719-731 (4) Huynh, THV; Shim, I; Bohr, H;Abrahamsen B; Nielsen, B; Jensen, AA and Bunch, L “Structure-Activity-Relationship Study of Selective EAAT1 Inhibitor UCPH-101 and Absolute Configurational Assignment using Infrared (IR) and Vibrational Circular Dichroism (VCD) Spectroscopy in Combination with Ab Initio Hartree-Fock Calculations” J. Med. Chem. 2012, 55, 5403-5412 |
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Patents (IPRs) |
WO/2010/066253: SELECTIVE INHIBITORS OF EXCITATORY AMINO ACID TRANSPORTER SUBTYPE 1 (EAAT1/GLAST) by L. Bunch and A. A. Jensen US Patent 20120035361: SELECTIVE INHIBITORS OF EXCITATORY AMINO ACID TRANSPORTER SUBTYPE 1 (EAAT1/GLAST) by L. Bunch and A. A. Jensen |
| Price and Availability |
- Contact us for bulk quantities (min 50 mg) -
The commercial rights to UCPH-101 are covered by patents listed above.
All IPRs belong to Hugin NeuroChemicalsResellers must sign aSupply and Onward Sales Agreement
For small quantity purchases, we kindly refer to our contract reseller: |